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标题: 头孢氨苄胶囊的人体生物等效性研究
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作者: 魏来 郑永 赵春景
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关键字词: 头孢氨苄 色谱法 药代动力学 生物利用度
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摘要: 目的研究不同厂家的头孢氨苄胶囊在人体内的生物等效性。方法对18名健屎志愿耆旱剂量口服给于不同生严厂豕的头记氨卞颗粒,以高效液相色谱法测定其血药浓度经时过程。结果受试制剂与参比制剂中头孢氨苄主要药代动力学参数达峰时间(Tmax)分别为(56.67±18.23)min和(61.67±24.62)min,峰浓度(Cmax)分别为(31.08±6.41)μg/mL和(29.95±6.56)μg/mL,0~300min药时曲线下面积(AUC0-300)分别为(3074.56±516.01)μg/(mL·min)和(
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