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标题: 546例丙戊酸钠血药浓度监测结果分析
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作者: 尹玉琴[1] 荆海霞[2] 赵益斌[1]
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关键字词: 丙戊酸钠 血药浓度 临床疗效 药物相互作用 不良反应
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摘要: 目的促进丙戊酸钠的临床合理应用。方法采用荧光偏振免疫分析法测定546例年龄为3个月~87岁的癫痫患者服用丙戊酸钠的797例次稳态血药浓度,并对结果进行分析。结果412例次(51.69%)丙戊酸钠血药浓度在有效治疗范围(50。100μg/mL)内,64例次(8.03%)高于100μg/mL,321例次(40.28%)低于50μg/mL;不同年龄段的血药浓度有效治疗范围无明显差异;服用丙戊酸钠缓释片后有63.37%的血药浓度在有效治疗范围内,明显高于普通片(50.29%);合用卡马西平、苯妥英钠时,可使丙戊酸
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