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标题: 家兔微血栓栓塞中风模型的建立及应用
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作者: 王维亭 于冰 赵专友 汤立达
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关键字词: 兔 动物模型 微血栓 脑栓塞 巴曲酶
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摘要: 目的研究脑血栓模型的建立及应用。方法采用微血栓经颈内动脉栓塞兔大脑中动脉的方法,建立微血栓栓塞中风模型并观察应用巴曲酶的效果。结果微栓子量达到(0.63±O.57)mg时可使一半动物出现中风症状,模型科学、可靠。巴曲酶0.5BU/kg治疗后6h能明显提高致半数卒中微栓子量(ES50),1.0BU/kg作用更明显,治疗后6h及24h ES50分别提高了2.2倍、1.8倍;巴曲酶1.0BU/kg给药后1h可使组织型纤溶酶原激活剂(t—PA)含量明显增加,较模型对照组增加了23.25%;巴曲酶0.5BU/kg及
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