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标题: 西酞普兰对脑卒中后抑郁状态和神经功能康复的影响及机制
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作者: 王宇林
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关键字词: 脑卒中 抑郁症 西酞普兰 P物质 神经肽Y 促肾上腺皮质激素释放激素
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摘要: 目的探讨西酞普兰对脑卒中后抑郁状态和神经功能康复的影响及作用机制。方法选择80例恢复期脑卒中抑郁状态患者,随机均分为两组,对照组40例予常规脑血管病治疗和康复训练,治疗组40例在对照组治疗基础上加用西酞普兰20mg,每日早饭后口服,疗程12周。两组患者分别于治疗前及治疗12周后采用汉密尔顿抑郁量表(HAMD)评定抑郁症状、临床神经功能缺损程度(NIHSS)评分评定神经功能、Barthel指数(BI)评定日常生活活动能力(ADL),采用放射免疫法测定血浆P物质(SP)、神经肽Y(NPY)和促肾上腺皮质激素释
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